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A filmmaker sets out to investigate the devastating migraine attacks that have her daughter in their grip, and decides to make a film about it. As mother and daughter seek understanding and ever-elusive treatment, we follow them into a bizarre and fascinating world populated by doctors, neuroscientists, other migraineurs, and such unexpected characters as Lewis Carroll, Sigmund Freud, and Joan Didion. We learn that, rather than a terrible headache, migraine is a complex, deeply stigmatized neurological disease afflicting nearly a billion people worldwide. This kaleidoscopic journey, told through interviews, cinema verite, art and animation, explores the history, impact and raw emotion evoked by this unpredictable and confounding condition.